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Clotrimazole cream 0.05 % Tretinoin 0.15% 0.16% Dosing of Acne. There was no apparent clinical benefit in the use of topical retinoids in the treatment of acne vulgaris. Acreage. Acne vulgaris can be considered a minor cosmetic malady. It is, however, a common disease of the skin, and when considered in relation to other cosmetic problems, the patient is entitled to reasonable expectations of improvement in the disease. Doses of topical retinoids up to 2.5% are usually considered sufficient. Pregnancy. There are no adequate and well-controlled studies relating the use of topical retinoids to teratogenic effects in pregnancy. However, because of an increased risk malignancies in offspring, women should be cautioned against using a retinoid cream regularly in pregnancy. Breast-feeding. There are no adequate and well-controlled studies relating the use of topical retinoids to teratogenic effects in breast-feeding. It is recommended that women use a retinoid cream only during breastfeeding. Nursing Mothers. There are no adequate and well-controlled studies relating the use of topical retinoids to teratogenic effects in nursing mothers. It is suggested that women who are breastfeeding should use a topical retinoid cream only when applied to the face, preferably by a nurse. Geriatric Use In a small number of patients, retinoids have been used in the treatment of mild to moderate acne. There is no convincing evidence of any teratogenic effect retinoids taken by the elderly in doses of 2.5% or higher. Geriatric Use not Generic brand for zyprexa Contraindicated There are no adequate and well-controlled studies relating the use of topical retinoids to teratogenic effects in elderly patients. It is suggested that elderly patients be cautioned against the use of topical retinoids. References 1. American Academy of Dermatology, "Drug Safety." 2. American Academy of Dermatology, "Drug Safety." 3. Dermatology. 1992;117(Suppl 2):S43-S48. 4. American Academy of Dermatology, "Drug Safety." 5. Food and Drug Administration, "Antimicrobial Drugs." 6. Breslow JE, Shulman GI. "Use of Retinoids for the Treatment Acne Vulgaris." Dermatology. 1994;129:S957-S964. 7. Breslow JE, Shulman GI. "Oral Retinoids for Acne Vulgaris: A New Approach." Journal of the American Academy Dermatological Science. 1993;28:S13-S22. 8. Breslow JE, Shulman GI. "Oral Retinoids for Acne Vulgaris: A Brief Report." Journal of the American Academy Dermatological Science. 1993;28:S22-S27. 9. National Institutes of Health. "Retinoids for the Treatment of Acne Vulgaris." National Institutes Health. June 2002; Available at: http://www.fda.gov/cder/drugsearch/searchresults.htm?v=FDA.drugid.1.0. 10. Roode JG, Schmitt ME. "A Comparison of Retinoids and Retinol with Retinol/Tretinoin for the Treatment of Acne Vulgaris." Journal Drugs in Dermatology. 2003;30:S27-S37.

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