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This study was not designed to determine whether bupropion treatment delays cognitive decline or the onset of cognitive decline in participants who did not have previous dementia; therefore, the findings of this study do not necessarily establish a causal relationship between bupropion and cognitive change. However, considering that bupropion was included in the group of medications assessed in clinical trials evaluating anti-CVD therapy for major depression, the results provide compelling evidence that chronic use of bupropion has potential to delay cognitive decline and potentially reduce risk of cognitive decline in at risk subpopulations, including individuals with dementia or an underlying cognitive disorder.
A limitation of the present review was that no specific dose-ranging data were provided for the different types of Bupropion that were prescribed to participants. These dose-ranging findings were based on participants' self-reported information. It is unknown whether bupropion at a different-dose level would result in different results. Future studies should be conducted to help delineate the effect of different doses bupropion on the Erythromycin purchase online cognitive decline and function of older individuals.
The results of this observational cohort study do not provide data for a causality analysis. Although it is not uncommon for individuals to use psychotropic medications, the study had several limitations: cross-sectional nature of the study; use participants with prevalent dementia and cognitive impairment; the cross-sectional design, possible confounder misclassification; the lack of longitudinal data; and the short observation period. Thus, there is no way to determine whether the study results translate to clinical practice or represent true therapeutic differences between Bupropion and placebo. However, this observational study is the first of its kind to examine the effect of Bupropion use on cognitive decline in older adults.
The study has several strengths, many of which are not readily drugstore brand makeup setting spray apparent at a first reading. These include the large sample size that provided sufficient power to examine the interaction of Bupropion Montair lc tablet price with age and dementia status, as well the relatively long follow-up, which allowed for examination of the effect multiple potential confounders. In addition, this study included participants who were at high risk for dementia and cognitive impairment, including a large proportion of participants with Alzheimer's disease or vascular dementia, which further reduces the potential for confounding by these conditions. Lastly, the assessment was based on a relatively large sample of participants from the same health care setting (see below).
The authors' conclusions on a potential effect of Bupropion are based on the participants' self-reported medication use. Although some may be concerned about the possibility that individuals may self-report medication use that or may not actually reflect medication use, the findings indicate that there was not a significant difference between participants taking bupropion and the non-takeers in terms of reported current Bupropion use.
Although the current study did not look at dose-ranging data, the lack of data may limit the ability to make any sort of inferences with respect to possible BUPRO-specific effects, as this study was an observational study. However, this was the largest study to date for Bupropion. Another limitation of the current study involves limited use of a validated instrument to monitor participants' cognitive function. Given the limited number of subjects that contributed data, there is insufficient reason Generic trazodone cost to suggest that the results are not reflective of true BUPRO-specific cognition. However, the limitation highlights need for ongoing studies to investigate the effectiveness and effects of different medications on the cognition of older adults in.
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