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Cymbalta is an atypical antipsychotic that blocks brain receptors for dopamine. It can dramatically reduce activity in the prefrontal cortex, an area responsible for planning and impulse control. In a study by Dr. Andrew Gelman, head of research at the Institute for Social Research at Goldsmiths, University of London, about half patients were prescribed Cymbalta. All of the patients developed severe depression and withdrawal symptoms. After withdrawing, Dr. Gelman said: "They were in a persistent downward spiral. They felt their lives were not worth living."
There is more evidence that Cymbalta doesn't work as well for treating mood swings, or maintaining improving in bipolar individuals with mild to moderate symptoms, as have been suggested by its manufacturer, Eli Lilly. In a 2013 study by researchers at the University of Rochester Medical Center in the United States, only 41 out of a total 80 patients who took Cymbalta for bipolar depression got better; and psychosis combined, only 36 of the 71 patients were Rosuvastatin 10mg $162.94 - $1.81 Per pill better.
A 2014 study in the journal PLoS One found that Cymbalta was not better than placebo or other antipsychotics in preventing relapse a cohort of patients with treatment-resistant depression. It reported that at any one time, 23 percent of those who started with placebo and went on to Cymbalta relapsed and 28 percent How much nolvadex during sustanon cycle on other antipsychotics.
Cymbalta's side effects are also well-documented. About one in four patients taking the drug experience weight gain for at least six months; another 5 percent have a rash, and 5 to 10 percent develop a new heart condition.
Cymbalta's price tag of more than $4,000 a month puts it closer to pricier medicines such as Lexapro, Zyprexa, and Celexa.
For patients in the United States, Cymbalta costs roughly $2,900 for a 12-week course of treatment, according to the manufacturer. However, patients often pay more because Cymbalta's price is so high. One study indicated that, in some circumstances, Cymbalta may cost twice as much expensive drugs for bipolar disorder — sometimes triple.
This is one of only two medication trials ever conducted for treatment-resistant depression. Two other trials, one of which was funded by Eli Lilly, looked at patients with bipolar depression only.
A 2013 review of Cymbalta's effectiveness from the British medical journal Lancet looked at three trials involving just 17 patients. In the trial, Cymbalta stopped depressive symptoms in only 15 of those patients. four the 17 who received Cymbalta reported that they felt better or had less depressive symptoms, including two who said the illness had been controlled or resolved completely.
What's the cost of drugs?
Cymbalta costs more than $250,000 per year for 12 weeks in the United States; this is more than the price of several other antianxiety medications, including Klonopin, Depakote, Xanax, Valium, and Wellbutrin. But that price tag may become so high that even those who need the drug may give up.
The most recent study released from Lilly looked at whether Cymbalta worked as well and how patients who were given Cymbalta fared. Patients who took a placebo, higher dose of Cymbalta, or one two other pills were compared to a group who did.
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